|
September
is Pain Awareness Month. This is your extra issue of APS
E-News.
Pharmacologic
Management of Neuropathic Pain: Evidence-Based Clinical Recommendations
APS
recently endorsed a new International Association for the Study
of Pain (IASP) guideline, Pharmacologic Management of Neuropathic
Pain: Evidence-Based Clinical Recommendations. Guideline developers
include the following international experts: Robert H. Dworkin,
Alec B. O'Connor, Miroslav Backonja, John T. Farrar, Troels
S. Jensen, Eija A. Kalso, John D. Loeser, Christine Miaskowski,
Turo J. Nurmikko, Russell K. Portenoy, Andrew S. C. Rice, Brett
R. Stacey, Rolf-Detlef Treede, Dennis C. Turk, and Mark S. Wallace.
Patients
with neuropathic pain (NP) are challenging to manage. NP is estimated
to afflict millions of people worldwide; many common diseases, injuries,
and interventions cause NP by producing lesions in somatosensory
neurons in the peripheral or central nervous system. The management
of patients with chronic NP is complex, and response to existing
treatments is often inadequate. Because of gaps and controversies
in the literature, considerable interpretation of available evidence,
judgment, and clinical experience are required to develop treatment
approaches that can be used in clinical practice. This guideline
panel convened with the following objectives: (a) review the results
of randomized controlled trials examining medications for the treatment
of NP; (b) develop up-to-date, evidence-based guidelines for the
pharmacologic management of NP that take into account clinical efficacy,
adverse effects, impact on health-related quality of life, convenience,
and costs; and (c) provide specific recommendations for the use
of these medications in clinical practice.
The
completed guidelines have been submitted for publication in The
Lancet.
New
Evaluation and Progress Report Card
The
University of Wisconsin Pain and Policy Studies Group (PPSG) will
release its new 2006 Evaluation
Guide and 2006 Progress Report Card this month. This new edition
of the Evaluation Guide is the third in a series of evaluations
of federal and state pain policies. The 2006 editions include a
more complete picture of the policy environment in each state, including
professional education, healthcare facility care standards, and
osteopathic practice. The Progress Report Card quantifies state
pain policies and benchmarks progress to promote pain management
and reduce policy barriers by comparing 2006 state policy grades
with those from 2000 and 2003.
News
Highlights from The Journal of Pain
The
following highlights summarize selected articles from the September
2006 issue (volume 7, number 9).
Factors
Associated with Delay to Analgesia in Emergency Departments
Glenn Arends and Margaret Fry, St. George Hospital, Kogara,
Australia
Waiting
time for administration of opiate analgesia is used to measure the
quality of care in hospital emergency departments. According to
the authors, it remains unclear if specific demographic and clinical
variables are associated with analgesia delays. Therefore, this
study set out to determine the percentage of emergency department
patients who require intravenous opiate analgesia and what, if any,
factors can predict when it might take more than an hour before
administration of the initial dose.
This
is the first study to establish a predictive model for delay to
analgesia. For 3 months, the authors examined medical records of
857 patients who received parenteral opiate analgesia in the emergency
department. They found that 52.6% were treated in less than 60 minutes.
For those who waited longer than 60 minutes, the study concluded
-
There is a perception among medical staff that patients with lower
emergency codes require less pain relief.
-
Patients seen by junior staff are more likely to experience analgesia
delay.
-
Medical staff are reluctant to provide analgesia to ED patients
when a diagnosis is not clear.
-
Three in four patients enduring analgesia delays do not receive
alternative pain relief prior to the administration of opioids.
The
authors recommended that triage nurse-initiated pain management
may offset inefficiencies in the timely delivery of analgesia. They
pointed out that expanding or introducing triage nurse-initiated
pain management can significantly reduce time to analgesia. Further,
studies show that nurse-initiated narcotic administration is safe
and efficient and can assist in the diagnostic process.
Symptom Profiles Differ in Patients with
Neuropathic vs. Non-Neuropathic Pain
Robert H. Dworkin, Mark P. Jensen, Arnold R. Gammaitoni, David
O. Olaleye, and Bradley S. Galer, University of Rochester School
of Medicine and Dentistry and University of Washington School of
Medicine
To
test their hypothesis that patients with neuropathic and non-neuropathic
pain have different symptom profiles, the authors examined 618 patients
with peripheral neuropathic pain conditions, osteoarthritis, and
low-back pain before their treatments had begun.
They
found that specific pain symptoms differ between patients with peripheral
neuropathic pain and those with inflammatory and musculoskeletal
pain. In particular, patients with neuropathic pain reported significantly
more hot, cold, sensitive, itchy, and surface pain. Non-neuropathic
pain subjects rated dull and deep pain as their most intense discomfort.
However, sharp pain, which usually is associated with neuropathic
conditions, was the only symptom with no discrimination between
the groups.
The
authors concluded that clinical methods should be developed for
characterizing pain symptoms, assisting in diagnosis, and providing
guides to underlying mechanisms and treatment targets.
A Reconsideration of the Relevance of Systemic
Low-Dose Ketamine to the Pathophysiology of Fibromyalgia
Patrick B. Wood, McGill University, Montreal, Canada
An
estimated 2% of the U.S. population has fibromyalgia, a condition
characterized by pain and tenderness to light palpation, chronic
fatigue, and sleep disturbances. Unlike patients with rheumatoid
arthritis, fibromyalgia patients have multisystem symptoms, suggesting
that pain from the disorder could be caused by impaired regulation
of the neurotransmitter dopamine. This finding casts doubt on previous
understanding that NDMA receptors contribute to fibromyalgia syndrome,
and that the disease can be managed with low-dose ketamine therapy.
Myers concluded that the growing body of evidence pointing to dopamine
dysregulation as a possible cause of fibromyalgia pain may explain
the heterogeneous symptom complex that characterizes fibromyalgia
syndrome.
Call
for SIG Members Interested in Pain in the Elderly
A group
of interested APS members is organizing a special interest group
(SIG) to focus on the unique aspects of the basic science, diagnosis,
and clinical aspects of pain in an older population. William Schwab,
MD PhD, Chief of Geriatrics for Ohio Permanente Medical Group, will
chair the SIG. If you would like to participate in this SIG, please
e-mail your interest to William.S.Schwab@kp.org
or call him at 216/470-2733. Please contact Dr. Schwab again even
if you have previously expressed interest in this SIG. Response
to date has been limited (less than 10 people), and Dr. Schwab is
pulling together a comprehensive list of interested persons.
APS
Volunteer Spotlight: Betty Ferrell, PhD RN
As
she advanced in her career as an oncology nurse, Betty Ferrell,
PhD RN, knew she wanted to be involved in pain research full time.
She fulfilled that dream 17 years ago when she joined City of Hope
National Medical Center as a research scientist.
Dr.
Ferrell's primary research focus is palliative care and patient
education. She received a grant from the National Cancer Institute
to develop an education program for pain and fatigue management.
An
APS member since 1987, Dr. Ferrell joined APS to take advantage
of opportunities to network with colleagues in pain research. "Before
the palliative care movement began, APS was the only resource for
researchers interested in pain care at the end of life," she said.
"Through the years, I have found APS to be a valuable source of
information and professional support through its publications, SIGs,
and the annual meeting. APS members can network with leaders in
their field and also benefit from the organization's advocacy efforts
on behalf of pain clinicians and researchers."
Dr.
Ferrell has a long record of service accomplishments as an APS volunteer.
She has contributed to publications and position statements on pain
in older adults, ethical issues in pain research, and pain management
nursing. She also is an active member of the APS Nursing SIG.
"I
strongly encourage fellows and students interested in pain research
to join APS," said Ferrell. The pain field still needs more young
researchers, and APS is an excellent source for mentors."
National
Headache Foundation Invites Research Grant Submissions
The National Headache Foundation (NHF) deadline for accepting research
protocols for funding consideration is December 1, 2006. If you
are interested in submitting a request, visit www.headaches.org/professional/educationindex.html
and look at the section "Research grants."
Pain
Control in the Primary Care Setting
Pain
Control in the Primary Care Setting is the first resource that
is appropriate for any healthcare provider—primary care physician,
medical and surgical specialist, nurse, physician assistant, psychologist,
physical therapist, and pharmacist—who is interested in improving
the management of chronic noncancer pain in the primary care setting.
Chronic noncancer pain management is often complex and includes
a challenging array of medical and psychosocial problems. The Greater
Philadelphia Pain Society, in collaboration with APS, developed
this handbook, which includes
-
principles of pain care
- pain
assessment and diagnosis
- pain
types and disorders
- pain
treatments
- case
studies
- professional
resources
- patient
education and resources
- medication
tables.
The
book also includes the following special topics:
-
knowing when and how to refer patients to specialists
- changing
or discontinuing ineffective treatments
- reducing
the risk of opioid abuse and diversion.
To
purchase a copy of Pain Control in the Primary Care Setting,
or for more information, visit our online
store.
Call
for Election Nominations: Coming Soon!
Are
you ready to pursue a national leadership position in APS?
Do
you demonstrate such leadership qualities as vision, strategic thinking,
motivation, and a sense of dedication to the society and its mission?
If
you answered yes to any or all of these questions, or if
this sounds like someone you know, the APS Nominating Committee
requests your election nomination. Open positions include President-Elect,
Treasurer, three Directors-at-Large,
and seven positions on the Nominating Committee.
Nominees must be active APS Regular Members and, most importantly,
want to achieve positive outcomes for the society, its members,
and those who are served by its efforts. Candidates will be elected
this winter to take office at the 2007 annual meeting.
Members
will receive an invitation to nominate potential election candidates
in October. Those with active e-mail addresses will be notified
by e-mail. Those without e-mail will receive instructions by mail.
In
addition, position descriptions, a list of current board and nomination
committee members and vacancies, and the disciplinary composition
and geographic representation of the board is available on the APS
Web site. APS has worked hard to make the nomination and voting
process easy for you; your participation will make it meaningful.
Please
take advantage of this opportunity. Your participation is important.
APS
Call for 2007 Paper and Poster Abstracts
Click
here to visit the call online. Submissions are due October
27, 2006.
|